Figure 2 (IMAGE)

Institute for Basic Science

Figure 2

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Laser microirradiation is used to mimic the DSBs in cells and measure the recruitment of green flurecent protein-labeled MSH2 (GFP-MSH2) or EXO1 (GFP-EXO1) to the DNA damage site (indicated by the red line) under a confocal microscope. The recruitment of GFP-MSH2 was inhibited in SMARCAD1-deficient cells, but not in EXO1-deficient cells. The recruitment of GFP-EXO1 was inhibited in SMARCAD1- or MSH2- deficient cells. These data indicates that MSH2 recruitment to DSBs depends on SMARCAD1, and then EXO1 is recruited.

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Institute for Basic Science

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