RPL3L mutation delays translational elongation of mRNAs involved in cardiac function (IMAGE)

Kyushu University

RPL3L mutation delays translational elongation of mRNAs involved in cardiac function

Caption

The team's analysis revealed that RPL3L-deficient hearts exhibited delayed translation rates at proline and alanine codons on mRNA. This 'translational traffic jam' resulted in misfolded proteins which would be cleared by the cell's quality control system. Many of the genes with abnormal translation rates were found to be related to heart contraction.

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Kyushu University/Nakayama Lab

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