Figure (IMAGE)

Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)

Figure

Caption

MIB1 mutations associated with bicuspid aortic valve. (a) Domain structure of the MIB1 protein, showing identified mutations associated with familial or sporadic bicuspid aortic valve. (b) Histological sections of the aortic valve in mice. Animals genetically engineered to carry mutations in MIB1 (MIB1K735R and MIB1V943F) and in another NOTCH pathway component (NOTCH or RBP) develop bicuspid aortic valve (asterisk in right panels).

Credit

CNIC

Usage Restrictions

No restrictions.

License

Public Domain

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.