Fig. 2 (IMAGE)

Osaka University

Fig. 2

Caption

Subclustering and pseudotime analysis of human cholesteatoma fibroblasts. Cholesteatoma fibroblasts were associated with five subclusters labeled 1, 7, 8, 10, and 11 (right panel). The most differentiated cells (labeled red) were identical to cholesteatoma fibroblasts in subcluster 8 (middle panel). Cholesteatoma fibroblasts showed high levels of INHBA expression, and the area of high INHBA expression was identical to the area in cholesteatoma fibroblasts in subcluster 8 (left panel).

Credit

2023, Masaru Ishii, Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction, Nature Communications

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