Diagram of neuroinflammation in endometriosis (IMAGE)
Caption
Researchers propose that IL-1β activates IL-1 type 1 membrane receptor (IL-1R1) in endometrial stromal cells, predominantly via the c-Jun N-terminal kinase (JNK) pathway, to promote neurotrophin and neurotrophin receptor (NTR) production and signaling, which in turn activate neurogenesis and pain. Parallel pathways promote IL-6 production and IL-1β autoregulation, potentially creating a vicious cycle of inflammation and pelvic pain. BDNF, brain-derived neurotrophic factor; NGF, nerve growth factor; SP, SP600125; TrkA/B, tropomyosin receptor kinase A/B.
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The American Journal of Pathology
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