The detail mechanisms of anti-tumor drugs targeting RNA modification (IMAGE)

Beijing Zhongke Journal Publising Co. Ltd.

The detail mechanisms of anti-tumor drugs targeting RNA modification

Caption

a. 18097 inhibits FTO to promote substrate mRNAs m6A level in breast cancer. b. HUHS015 disturbs ALKBH3 functioning as prostate cancer antigen 1. c. R-2HG prevents FTO removing m6A from MYC/CEBPα in AML. d. WBSCR22 knockdown enhances the sensitivity of colorectal cancer cells to oxaliplatin. e. METTL1/NSUN2 knockdown facilitates cervical cancer cells being sensitive to 5-FU. f. NSUN3/DNMT2/CDK7/HnRNPK/CDK9/p-TEFb complex binding nascent nuclear RNA, forms a 5-AZA-sensitive chromatin structure in AML.

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Beijing Zhongke Journal Publising Co. Ltd.

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