Fig. 3 (IMAGE) Osaka University Caption Conformational change of cofactor TPQ during the catalysis. TPQ undertakes a conformational change from off-Cu to on-Cu in a manner that generates a semiquinone radical intermediate. Credit Takeshi Murakawa, Toshihide Okajima Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.