image: Young adults had higher proportion of a specific T cell, the interferon-γ(IFNγ)-secreting CD4+ T-cells, which is associated with more antibody responses and stronger virus neutralisation. Conversely, this relationship was negative in older adults, suggesting that older adults’ relative IFNγ-secreting CD4+ T-cell deficiency might explain their weaker immune response to vaccination
Credit: Diego Araujo, National University Health System
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PhD student, Department of Microbiology and Immunology; Immunology and Infectious Diseases Translational Research Programmes, Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine)
Associate Consultant, Division of Geriatric Medicine, Department of Medicine, National University Hospital (NUH)
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何文婷博士
新加坡国立大学杨潞龄医学院 微生物学和免疫学系 免疫转化研究项目及感染科转化研究项目 博士生
国立大学医院内科部门老年医学科 副顾问医生
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Division of Infectious Diseases, Department of Medicine, National University Hospital (NUH)
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传染病科 |
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Agency for Science, Technology and Research Infectious Diseases Labs (A*STAR ID Labs)
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新加坡科技研究局 新科研传染病研究所
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National Centre for Infectious Diseases (NCID)
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国家传染病中心 |
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NUS Medicine Infectious Diseases Translational Research Programme Seed Fund
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新加坡国立大学杨潞龄医学院 感染科转化研究项目种子资金
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NUH COVID-19 Adhoc Fund
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国立大学医院(国大医院)冠病临时基金 |
Journal
Aging Cell
Method of Research
Observational study
Subject of Research
People
Article Title
Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults
Article Publication Date
5-Feb-2024