image: The Patient-Centered Outcomes Research Institute (PCORI) is the nation’s leading funder of patient-centered comparative clinical effectiveness research (CER). By comparing two or more health or healthcare approaches, CER generates evidence that helps people make better-informed decisions and improves healthcare delivery and outcomes. PCORI takes a holistic approach to its work, ensuring that patients and other health decision makers are engaged as partners throughout the research process, supporting dissemination and implementation of results in practice and strengthening clinical research infrastructure to advance patient-centered CER. PCORI is an independent, non-profit organization authorized by Congress. Visit pcori.org.
Credit: Patient-Centered Outcomes Research Institute
WASHINGTON, D.C. — The Patient-Centered Outcomes Research Institute (PCORI) is inviting proposals for new patient-centered comparative clinical effectiveness research (CER) studies and research-related projects through eight PCORI Funding Announcements (PFAs), offering more than $500 million in potential funding.
“These first funding opportunities of 2025 demonstrate PCORI’s commitment as the nation’s leading funder of patient-centered comparative clinical effectiveness research,” said PCORI Executive Director Nakela L. Cook, M.D., MPH. “The research funded through these opportunities will generate valuable insights to help people make better informed healthcare decisions and improve healthcare delivery for a range of conditions.”
PCORI has committed up to $200 million for patient-centered CER focused on two of the organization’s Research Project Agenda Topic Themes addressing critical health challenges affecting millions of people living in the United States.
- Up to $100 million for patient-centered CER on managing pain, including, but not limited to, studies on urogynecological and pelvic pain, limitations in cognitive functioning, sickle cell disease and neuropathy.
- Up to $100 million for patient-centered CER on improving mental and behavioral health, including, but not limited to, studies focusing on children and youth, suicide prevention and crisis response and strategies to improve mental health care access and delivery.
Additional CER funding opportunities include:
- Up to $200 million through the Phased Large Awards for Comparative Clinical Effectiveness Research PFA, which seeks proposals for ambitious, large-scale two-phased trials addressing critical decisional dilemmas requiring new evidence about the comparative effectiveness of available interventions.
- Up to $160 million through the Broad Pragmatic Studies PFA, with special interest in submissions on social isolation and loneliness among older adults and health communication strategies for COVID-19 vaccine uptake.
PCORI is also accepting proposals for:
- Implementation projects to promote the use of results from PCORI-funded CER (up to $23.5 million).
- Methods development for conducting CER (up to $12 million).
- Science of engagement in CER (up to $36 million).
“These funding opportunities contribute to the knowledge and resources needed to conduct rigorous, stakeholder-engaged patient-centered comparative clinical effectiveness research and support the adoption of findings in care settings, where they can support health and healthcare decisions people across the United States are making every day,” said PCORI Deputy Executive Director for Patient-Centered Research Programs Harv Feldman, M.D., MSCE.
Awarded funding totals within and across PFAs are subject to the quantity and quality of applications received. To date, PCORI has awarded more than $4.5 billion to fund patient-centered CER studies and research-related projects. Details about the most recent funding announcements are on PCORI’s website.
About PCORI
The Patient-Centered Outcomes Research Institute (PCORI) is the nation’s leading funder of patient-centered comparative clinical effectiveness research (CER). By comparing two or more health or healthcare approaches, CER generates evidence that helps people make better-informed decisions and improves healthcare delivery and outcomes. PCORI takes a holistic approach to its work, ensuring that patients and other health decision makers are engaged as partners throughout the research process, supporting dissemination and implementation of results in practice and strengthening clinical research infrastructure to advance patient-centered CER. PCORI is an independent, non-profit organization authorized by Congress. Visit pcori.org.