News Release

Characterizing olfactory brain responses in young infants

Imaging study reveals that infants as young as 1-month old process odors, shedding light on how early neural processes for the sense of smell develop in humans.

Peer-Reviewed Publication

Society for Neuroscience

Approach to neuroimaging infants

image: 

Shown are depictions of nasal mask positioning (a), how infants were secured into the imaging scanner, (b), the timeline in which researchers recorded nasal airflow as they presented infants with odors (red and blue clouds) or clean air (gray cloud), and a description of the specific odors that researchers presented to infants (d).

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Credit: Shanahan et al., JNeurosci 2025

The sense of smell promotes adaptive behaviors such as feeding and soothing, but how early humans begin to process odors represents a gap in knowledge for researchers. In a new study in JNeurosci, Thorsten Kahnt from the National Institute on Drug Abuse and colleagues explored olfaction development in humans and reveal how early humans begin to smell. The researchers used fMRI to image the brains of sleeping infants as they inhaled appetitive (pleasant) and aversive (unpleasant) odors. As early as one month of age, odors triggered activity in brain regions strongly associated with the sense of smell, as well as the thalamus, which is important for processing sensory information in general. The strength of activation varied across odors, but unlike what is observed in adults, distinct odors did not trigger unique activation patterns. Additionally, nasal airflow findings from this study suggest that sleeping infants inhale more vigorously when scents are appetitive than aversive.  

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Manuscript title: Characterizing Olfactory Brain Responses in Young Infants

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About JNeurosci

JNeurosci, the Society for Neuroscience's first journal, was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship.

About The Society for Neuroscience

The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 35,000 members in more than 95 countries.


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