Estrogen partially restores progesterone production and ovarian health in mice with lysosomal storage disorder

A recent study published in Reproductive and Developmental Medicine has revealed that estrogen can partially restore progesterone levels and improve ovarian health in Mcoln1^−/− mice, which serve as a model for human mucolipidosis type IV (a type of lysosomal storage disorder). These mice have premature luteolysis leading to progesterone deficiency and infertility.

A research team from the University of Georgia treated Mcoln1^−/− mice with hormone therapies, including progesterone, estrogen, or a combination of both. Results showed that a high level of estrogen significantly increased serum progesterone levels  while progesterone alone lacked such effect in Mcoln1^−/− mice. The estrogen treatment also improved the morphology of Mcoln1^−/− luteal cells in the ovary, indicative of improved lysosomal function. This research could provide insights into treating progesterone insufficiency.