image: Figure A shows the age-standardized incidence and mortality of cervical cancer worldwide in 2022. The blue diamond represents the regional rate, the black vertical line represents the country rate, and the blue dashed line represents the WHO Cervical Cancer Elimination Initiative goal (4 cases per 100,000). Figure B shows the association between the HDI and ASIR and ASMR for cervical cancer in 2022. There is a clear socioeconomic disparity in ASIR and ASMR in cervical cancer, with regions characterized by lower HDI having higher ASIR and ASMR for cervical cancer. ASIR: age-standardized incidence rates, ASMR: age-standardized incidence mortality rates.
Credit: ©Science China Press
The authors analyzed the incidence and mortality of cervical cancer in 185 countries and regions using data from the GLOBOCAN 2022 database. The incidence data of cervical cancer in 36 countries from 2003 to 2017 were collected from the Cancer Incidence in Five Continents plus Database (CI5 plus) to calculate the incidence trend.
In 2022, there were 622,301 cervical cancer cases worldwide, with an age-standardized incidence rates (ASIR) of 14.1 per 100,000. Geographically, the highest ASIR was observed in East Africa (40.4 per 100,000), and the lowest in Western Asia (4.2 per 100,000). There were 348,874 cervical cancer deaths worldwide, with an age-standardized mortality rates (ASMR) of 7.1 per 100,000. The highest ASMR was in East Africa, followed by Central Africa, and South Africa. There existed negative correlations between Human Development Index (HDI) and the ASIR, ASMR and mortality to incidence ratio (MIR) of cervical cancer. Among the 36 countries with incidence data of trend, 7 exhibited significant increases in their ASIRs with average annual percent changes (AAPCs) ranging from 0.9% to 5.9%, while 14 countries demonstrated significant decreases in their ASIRs with AAPCs ranging from −0.8% to −5.9%.
Cervical cancer continues to represent a substantial global health burden. It is necessary to formulate and improve targeted cervical cancer prevention and control programs for different regions, especially in low-income countries should give priority to promoting HPV vaccination so as to provide a practical path for realizing the goals of the WHO Global Cervical Cancer Elimination Initiative.
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Medicine Plus