Researchers identify a key biological mechanism that promotes healthy aging

A study published in Aging Cell has identified immune resilience as a key driver of salutogenesis—the active process of promoting health and well-being.

By analyzing data from 17,500 individuals across various life stages, investigators uncovered the importance of immune resilience involving TCF7, a gene essential for maintaining immune cell regenerative potential, in fostering healthy aging and longevity.

The research indicates that immune resilience counters three major factors of aging and mortality: chronic inflammation, immune system decline (immunosenescence), and cell death. This protective mechanism mitigates biological aging processes and confers survival advantages. For example, at age 40, individuals with poor immune resilience face a 9.7-fold higher mortality risk—a risk equivalent to that of 55.5-year-olds with optimal immune resilience, resulting in a 15.5-year survival gap.

Maintaining optimal immune resilience preserves youthful immune profiles at any age; enhances vaccine responses; and significantly reduces the burden of cardiovascular disease, Alzheimer’s disease, and severe infections.

Midlife (ages 40–70) emerges as a pivotal window for longevity, with immune resilience reducing mortality by 69% during this period. However, after age 70, mortality rates converge between resilient and non-resilient groups, suggesting biological limits on lifespan extension. These findings underscore the importance of early midlife interventions to boost immune resilience to maximize healthspan.

“While most aging research focuses on disease mechanisms and the biology of aging, our work highlights how immune resilience sustains salutogenesis—actively promoting health,” said senior author Sunil K. Ahuja, MD, of UT Health San Antonio and the South Texas Veterans Health Care System. “This opens new avenues for strategies to enhance lifelong wellness.”

URL upon publication: https://onlinelibrary.wiley.com/doi/10.1111/acel.70063

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About the Journal
Aging Cell is an open access geroscience journal publishing research addressing the biology of aging. The journal welcomes research that reports the mechanistic, molecular, and cellular aspects of the aging process, as well as the links between aging and age-related disease.

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