Indianapolis, Indiana – October 12, 2025 – The latest research advances and scientific discoveries in otolaryngology-head and neck surgery were presented during the American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF) 2025 Annual Meeting & OTO EXPO. From hundreds of research presentations submitted, the Annual Meeting Program Committee selected 19 exceptional studies as the "Best of Scientific Oral Presentations," recognizing their potential to further patient care and advance the field.
The Best of Scientific Oral Presentations represent the forefront of medical discovery—from artificial intelligence applications that enhance diagnostic accuracy and reduce physician burnout, and novel therapeutic approaches that preserve hearing and prevent complications, to improved surgical techniques that increase success rates and reduce recovery time, and quality improvement initiatives that strengthen emergency response.
Each study was rigorously evaluated and selected for its scientific merit, clinical relevance, and potential to improve outcomes for patients with ear, nose, throat, and head and neck conditions. These advances translate directly to improved diagnosis, treatment options, and outcomes for the millions of patients who seek care for ear, nose, throat, and head and neck conditions each year.
"The scientific program at our Annual Meeting represents the very best in otolaryngologic research," said Cecelia Damask, AAO-HNSF Annual Meeting Program Coordinator. "These presentations demonstrate an ongoing commitment to evidence-based medicine and continuous advancement in patient care. The diverse range of topics—from sleep apnea and hearing loss to cancer treatment and pediatric airway management—reflects the breadth and depth of innovation occurring in our specialty."
The 2025 "Best of Scientific Oral Presentations"
A Novel Predictive Scoring System for Hypoglossal Nerve Stimulation Outcomes in Obstructive Sleep Apnea Patients [Jaehee Kim, BA, (Presenting Author); Shashank Singh, PhD; Tyler J. Allcroft; Navin N. Rana; Praneet Kaki, BS; Colin T. Huntley, MD (Senior Author)]
OSA affects approximately 30 million Americans and is linked to cardiovascular disease, diabetes, and reduced quality of life. This study introduces a comprehensive predictive scoring system to improve patient selection for hypoglossal nerve stimulation (HNS) therapy in obstructive sleep apnea (OSA). Researchers developed and validated a model incorporating clinical and demographic factors to predict treatment success, potentially helping clinicians identify ideal candidates and improve therapeutic outcomes for this increasingly utilized surgical intervention.
Accuracy of ChatGPT-4o in Supervising Residents in Otolaryngology-Head and Neck Surgery: A Randomized Controlled Trial [Lise Sogalow, MD (Presenting Author); Meryem Miri, MD (Presenting Author); Jerome R. Lechien, MD, PhD; Antonino Maniaci, MD, PhD; Carlos M Chiesa-Estomba, PhD; Sarah Saxena, MD; Stephane Hans, MD, PhD; Giovanni Briganti, MD (Senior Author)]
In this innovative randomized controlled trial, investigators evaluated the accuracy and reliability of ChatGPT-4o as a supervisory tool for otolaryngology residents. The study assessed the artificial intelligence system's ability to provide clinical guidance, educational feedback, and decision support, offering insights into the potential role of AI-assisted learning in surgical residency education.
Adherence to Bell's Palsy Clinical Practice Guidelines: A Nationwide Retrospective Analysis [Nicole M. Favre, MD (Presenting Author); Mattie R. Rosi-Schumacher, MD; Ariel Harsinay, BS; David A. Sherris, MD (Senior Author)]
This nationwide retrospective study examined adherence patterns to established clinical practice guidelines for Bell's palsy management across the United States. Researchers analyzed treatment variations, identified barriers to guideline implementation, and highlighted opportunities to improve standardized care for patients with this common facial nerve disorder.
Antigen Removal Strategy in Laryngeal Tissue Engineering Mitigates Extracellular Matrix Collagen Degradation [Emily G. Hardy, BS (Presenting Author); Amanda Richards; Cheryl Myers, PhD; David G. Lott, MD (Senior Author)]
Researchers developed a novel antigen removal approach in laryngeal tissue engineering that significantly reduces extracellular matrix collagen degradation. This advancement addresses a critical challenge in developing bioengineered laryngeal tissues and may pave the way for improved reconstructive options for patients with laryngeal disorders or injuries.
Assessing the Quality and Efficiency of an Artificial Intelligence Powered Scribe in Outpatient Clinic Visits [Bryan A. Renslo, MD (Presenting Author); Chase Kahn, MD; David M. Cognetti, MD (Senior Author)]
This study evaluated the implementation of AI-powered medical scribes in otolaryngology outpatient settings, measuring impacts on documentation quality, clinical efficiency, and physician satisfaction. The findings provide valuable insights into how emerging technologies can reduce administrative burden while maintaining high-quality patient care and medical record accuracy.
Computer Vision Model for Automated Detection of Abnormal Pediatric Vocal Cord Movement on Video Laryngoscopy [Yasmine Madan, BSc (Presenting Author); Nida Copty; Karan S. Chahal; Frank Chen; Paul Esemu-Ezewu; Nikolaus Ernst E. Wolter, MD, MSc; Evan J. Propst, MD, MSc; Clyde Matava, MD; Jennifer M. Siu, MD, MPH (Senior Author)]
Investigators developed and tested a computer vision model capable of automatically detecting abnormal vocal cord movement patterns in pediatric patients during video laryngoscopy. This artificial intelligence application has the potential to enhance diagnostic accuracy, reduce interpretation variability, and expedite identification of pediatric airway pathology.
Development of Novel mRNA Classifiers to Stratify Preoperative Thyroid Tumor Risk [Thomas F. Barrett, Jr., MD (Presenting Author); Joshua Klopper, MD (Presenting Author); Mohammed Alshalalfa, PhD; Yangyang Hao, PhD; Richard A. Harbison, MD, MS (Senior Author)]
This research presents newly developed mRNA-based classifiers that improve preoperative risk stratification for thyroid tumors. The molecular diagnostic tool may help clinicians better distinguish between benign and malignant thyroid nodules, potentially reducing unnecessary surgeries while ensuring appropriate intervention for high-risk lesions.
Gender Disparities in Research Leadership: Trending Female Representation in Otolaryngology Clinical Trials [Sandhya Ganesan, BS (Presenting Author); Myra A. Zaheer, BA; Leena Y. Zitoun, BS; Henna Tiwary; Sarah K. Fangmeyer, DO; Lwam T. Asfaw, BS; Punam G. Thakkar, MD (Senior Author)]
This comprehensive analysis examined gender representation in leadership positions within otolaryngology clinical trials, tracking trends over time and identifying persistent disparities. The study provides critical data to inform diversity and inclusion initiatives, highlighting the importance of equitable representation in research leadership.
How Do Patient Comorbidities Impact Adult Cochlear Implant Outcomes? [Barak M. Spector (Presenting Author); Priya Bandaru; Tam Nguyen; Sandra Simmons, PhD; Aaron C. Moberly, MD; Terrin Tamati, PhD (Senior Author)]
Researchers investigated the relationship between patient comorbidities and cochlear implant outcomes in adult recipients. The study identified specific health conditions that may influence hearing restoration success, providing clinicians with evidence-based insights to optimize patient counseling, candidate selection, and postoperative expectations, helping address hearing loss that affects 48 million Americans.
Influence of Surgeon Specialty on Tracheostomy Outcomes [George S. Bebawy, BA (Presenting Author); David Herz, BS; Aman M. Patel, MD; Victoria O. Youssef, BA; Ghayoour S. Mir, DO (Senior Author)]
This investigation analyzed how surgeon specialty training affects tracheostomy complication rates and patient outcomes. By comparing results across different surgical specialties, the study offers important evidence regarding optimal provider selection and potential opportunities for improved training and quality improvement initiatives.
Nanopore Sequencing Detects Prevalence of HPV DNA in Pediatric and Young Adult Archival Tonsil Specimens [Mikayla G. Hubbard, BS (Presenting Author); Thomas E. Davis, MD, PhD; Guang-Sheng Lei, PhD; Robert E. Emerson, MD; Danielle Schreiber, ASCP; Diane W. Chen, MD (Senior Author)]
Using advanced nanopore sequencing technology, researchers detected and characterized human papillomavirus (HPV) DNA in archival tonsil specimens from pediatric and young adult patients. This work enhances understanding of HPV epidemiology in younger populations and may inform future vaccination strategies and disease prevention efforts.
Olfactory Retraining Protocol for Post-Viral Anosmia: A Prospective Cohort Study [Naomi C. Wang, MD (Presenting Author); Angela L. Kaczorowski-Worthley (Presenting Author); Maria Feucht, MD; Amelia Lawrence; Rahul Alapati, MD; Jennifer A. Villwock, MD (Senior Author)]
This prospective cohort study, which is particularly relevant following widespread COVID-19-related smell loss affecting millions, evaluated a structured olfactory retraining protocol for patients experiencing post-viral anosmia (loss of smell). The research provides evidence regarding treatment efficacy, optimal training duration, and patient factors associated with smell recovery, offering hope for individuals affected by this increasingly recognized condition.
Outcomes of Surgical Repair for Large Nasal Septal Perforations: A Systematic Review and Meta-Analysis [Matthew HZ Cheung, BS (Presenting Author); Cory Hyun-su Kim, BS; Shaun A. Nguyen, MD; Michaela F. Close, MD; Vusala Snyder, MD, MS; Michelle S. Hwang, MD (Senior Author)]
Through systematic review and meta-analysis of existing literature, researchers comprehensively evaluated surgical outcomes for large nasal septal perforation repair. The study synthesized evidence regarding success rates, surgical techniques, and complications, providing clinicians with evidence-based guidance for managing this challenging condition.
PEAK-II Trach: A Multi-Institutional Quality Improvement / Simulation Study Assessing Pediatric Airway Emergency Readiness [Olivia E. Dunne, BS (Presenting Author); Jonathan Biel, BS; Amanda H. Shen, MS; Roxanna Mosavian, BA; Marc-Mina N. Tawfik, BS; Regine M. Fortunov, MD; Akira Nishisaki, MD, MSCE; Tensing Maa, MD; Ilana Harwaye-Gidansky, MD, MA; Elliot Schiff, BA; Monira Albathi, MBBS, MPH; Meredith Merz Lind, MD; Pooja A Nawathe, MD; Daniel Chiou, MD; Ankona Ghosh, MD; Alanna M. Windsor, MD; Adam J. Van Horn, MD; Kamal Abulebda, MD; Kristin Van Genderen, MD; Lindsay R. Koressel, MD, MEd; Adrian Zurca, MD, MEd; Todd Chang, MD, MAcM; James W. Beal, DO; Christina J. Yang, MD, MS (Senior Author)]
This multi-institutional quality improvement initiative assessed and enhanced pediatric airway emergency readiness through standardized simulation training for tracheostomy emergencies. The PEAK-II Trach program demonstrated measurable improvements in provider preparedness, response time, and clinical competency in managing critical pediatric airway situations.
Quantitative Evaluation of Ciprofloxacin-Dexamethasone in a Novel Animal Model of Subglottic and Tracheostomy-Related Stenosis [Travis Peng (Presenting Author); Pooja N. Swami, MS; Rachel J. Kaye, MD; Seth E. Kaplan, MD; Matthew I. Saleem, BS; Patrick Scheffler, MD; Daniel A. Grande, Jr., PhD; Lee P. Smith, MD (Senior Author)]
Investigators developed a novel animal model to quantitatively evaluate ciprofloxacin-dexamethasone treatment for subglottic and tracheostomy-related stenosis. The research provides preclinical evidence for this therapeutic approach and establishes a validated model for future investigations of stenosis prevention and treatment strategies.
Rescue Treatment with Losartan Induces Sustained Hearing Protection After Acoustic Trauma in Mice [Sepehr Salehpour, MD (Presenting Author); Carolina Chu, MS; Steffen Osborn, BS, BBA; Daniel C. Bartelt, BS; Marlan R. Hansen, MD; Douglas M. Bennion, MD PhD (Senior Author)]
This groundbreaking study demonstrated that losartan, an angiotensin receptor blocker, provides sustained hearing protection when administered as rescue treatment following acoustic trauma in a mouse model. The findings suggest a potential new therapeutic avenue for preventing noise-induced hearing loss in humans exposed to harmful sound levels.
The Effect of Obstructive Sleep Apnea on Wound Healing: Insights from a Murine Model [Dor Maayan, MD (Presenting Author); Offir Ertracht, PhD; Itzhak Braverman, MD; David Rengifo, MD; Mahmoud Darawshe, MD; Rodrigo Martinez Monedero, MD; Shaul Atar, MD; Forsan Jahshan, MD (Senior Author)]
Using a murine model, researchers investigated how obstructive sleep apnea affects wound healing processes at the cellular and molecular levels. The study revealed important mechanistic insights that may explain delayed healing observed in OSA patients and could inform perioperative management strategies to improve surgical outcomes.
Three-Year Survival Outcomes of Neoadjuvant Nivolumab-IDO Inhibition in Head and Neck Squamous Cell Carcinoma Patients [Kalena H. Liu, BS (Presenting Author); Hani Samarah, BS (Presenting Author); Eric V. Mastrolonardo, MD; David M. Cognetti, MD; Joseph M. Curry, MD; Adam J. Luginbuhl, MD (Senior Author)]
This study reported three-year survival outcomes for head and neck squamous cell carcinoma patients treated with neoadjuvant nivolumab combined with IDO inhibition. The long-term follow-up data provides critical evidence regarding the efficacy and durability of this immunotherapy approach, potentially influencing treatment paradigms for this challenging cancer.
Utility of Coagulation Studies and Hematology Consults in Post-tonsillectomy Hemorrhage [Angela T. Cao, MD (Presenting Author) and Michael A. DeMarcantonio, MD (Senior Author)]
Researchers evaluated the clinical utility and cost-effectiveness of obtaining coagulation studies and hematology consultations in patients experiencing post-tonsillectomy hemorrhage. The findings offer evidence-based guidance for diagnostic workup protocols and resource utilization in managing this common postoperative complication.
About the AAO-HNSF 2025 Annual Meeting & OTO EXPO
The AAO-HNSF Annual Meeting & OTO EXPO is the premier education and scientific forum for otolaryngology-head and neck surgery, bringing together thousands of specialists, researchers, and industry partners to advance the field and patient care. The meeting features hundreds of scientific presentations, education courses, and networking opportunities designed to disseminate the latest research findings and clinical innovations.
The AAO-HNSF's scientific program serves as a cornerstone for innovation in otolaryngology, bringing together leading researchers, clinicians, and specialists to share cutting-edge findings that directly impact clinical practice.
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About the AAO-HNS/F
The AAO-HNS/F is one of the world’s largest organizations representing specialists who treat the ears, nose, throat, and related structures of the head and neck. Otolaryngologist-head and neck surgeons diagnose and treat medical disorders that are among the most common affecting patients of all ages in the United States and around the world. Those medical conditions include chronic ear disease, hearing and balance disorders, hearing loss, sinusitis, snoring and sleep apnea, allergies, swallowing disorders, nosebleeds, hoarseness, dizziness, and tumors of the head and neck as well as aesthetic and reconstructive surgery and intricate micro-surgical procedures of the head and neck. The Academy has approximately 13,000 members. The AAO-HNS Foundation works to advance the art, science, and ethical practice of otolaryngology-head and neck surgery through education, research, and quality measurement.