About The Study: In trials of depression, psychedelic-assisted therapy (PAT) was not more effective than open-label traditional antidepressants (TADs). Blinding made a difference for TADs, but not for PAT, confirming that PAT trials are effectively always open label. These results argue against highly optimistic narratives surrounding PAT and highlight the importance of blinding integrity.
Corresponding Author: To contact the corresponding author, Balázs Szigeti, PhD, email balazs.szigeti@ucsf.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(10.1001/jamapsychiatry.2025.4809)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2025.4809?guestAccessKey=d844d09d-abaf-4310-887c-e13957d27905&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=031826
Journal
JAMA Psychiatry