About The Study: In this population-based cohort study, a sibling-matched analysis found no evidence of an association between prenatal paracetamol (acetaminophen) exposure and the risk of autism spectrum disorder or attention-deficit/hyperactivity disorder (ADHD) in offspring. The positive signals observed in conventional studies are likely attributable to residual familial confounding. These findings provide important reassurance regarding the safety of indicated paracetamol use during pregnancy.
Corresponding Authors: To contact the corresponding authors, email Eric Yuk Fai Wan, PhD, (yfwan@hku.hk) and Ian Chi Kei Wong, PhD, (i.wong1@aston.ac.uk).
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamainternmed.2026.2215)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2026.2215?guestAccessKey=41c1ba2f-5a8b-4b37-a8b9-10f0073bb1d8&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=062926
Journal
JAMA Internal Medicine