About The Study: In this case report, areas of extensive amyloid clearance after amyloid-targeting therapy were associated with less downstream neuropathologic change. In addition, amyloid clearance appears to preferentially occur in the gyral crests. Future studies should evaluate the differential mechanisms involved in amyloid clearance from superficial and deep cortical layers and in gyri and sulci because extensive amyloid clearance may be necessary to achieve downstream neuropathologic benefit after removal of amyloid.
Corresponding Author: To contact the corresponding author, Edward B. Lee, MD, PhD, email edward.lee@pennmedicine.upenn.edu.
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(doi:10.1001/jama.2026.13058)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the Alzheimer’s Association International Conference.
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Journal
JAMA