News Release

Waste coffee grounds could someday help detect brain waves

Reports and Proceedings

American Chemical Society

SAN DIEGO, March 20, 2022 — There’s nothing like a steaming cup of joe to give your morning a quick boost. Now, there’s yet another reason to love the beverage. Today, researchers report the first application of used coffee grounds as environmentally friendly electrode coatings for sensitive neurochemistry measurements. The material could eventually help scientists get a better handle on brain activity and detect minute levels of neurotransmitters.

The researchers will present their results at the spring meeting of the American Chemical Society (ACS). ACS Spring 2022 is a hybrid meeting being held virtually and in-person March 20-24, with on-demand access available March 21-April 8. The meeting features more than 12,000 presentations on a wide range of science topics.

Spent coffee grounds have previously been used to make porous carbon supercapacitors for energy storage. But now, new research led by principal investigator Ashley Ross, Ph.D., has taken recycled coffee waste in another, more biological direction. She and her team have demonstrated that electrodes coated with carbon from this waste can detect trace levels of biomolecules in vitro. According to Ross, this is the first example of residual coffee grounds being repurposed for biosensing applications.

“I saw papers about using spent grounds to produce porous carbon for energy storage, and I thought maybe we could use this conductive material in our neurochemistry detection work,” says Ross. “And I also thought this would be a good excuse to buy lots of coffee for the lab!” Ross, who is at the University of Cincinnati, and several members of her team are self-professed coffee lovers.

The traditional microelectrodes that neuroscientists use are commonly made from carbon fiber — fine, solid carbon strands bundled together. Making them is typically an arduous and expensive process, involving multiple steps and harsh chemicals. Eventually, Ross wants to fabricate entire electrodes with carbon from coffee grounds because this type of approach would be inexpensive and environmentally friendly. As a first step toward realizing that goal, the researchers adapted the material from the grounds as a coating for conventional electrodes.

Kamya Lapsley, who was a summer student in Ross’s lab and who is currently an undergraduate student at Kent State University, took this initial challenge on. She and other members of the lab dried used coffee grounds and heated them in a tube furnace at about 1,300 F. Next, they added the material to a potassium hydroxide solution to activate the carbon and open up holes in the structure. Then, the researchers heated the mixture again under nitrogen gas to remove any undesired byproducts. What was left was an inky slurry full of flecks of porous carbon. As a final step, the researchers diluted the sludge with water, into which they dipped the carbon fiber electrodes to coat them with a layer of porous carbon nearly a hundred times thinner than the diameter of a human hair. 

The researchers compared the performance of coated and uncoated electrodes for sensing small quantities of dopamine, a neurotransmitter, with fast-scan cyclic voltammetry. With this technique, they applied a rapidly varying voltage to the electrode to alternately oxidize and reduce dopamine. The technique is fast enough to detect subsecond neurotransmitter release, as would happen in the brain. The researchers found that electrodes coated with porous carbon reached oxidative current levels over three times higher than bare carbon fibers in the presence of dopamine, indicating that the coated electrode offered a more sensitive surface for dopamine detection. Not only does the porous structure allow more dopamine molecules to participate in the reaction because of the coating’s large surface area, it also momentarily traps dopamine molecules in the crevices of the electrode, says Ross. These properties increase the sensitivity and allow the researchers to carry out faster measurements. The group is now exploring how these porous coatings impact the temporal resolution of the technique.

Next, the team will make carbon fiber electrodes from scratch with porous carbon from waste coffee grounds, which would give the electrodes uniform porosity not just on the surface, but also through and through. Ross predicts that this will boost their neurochemical detection abilities because an even larger total surface area of the electrode will be exposed to adsorb the dopamine molecules. At the same time, Ross plans to put the current coffee-coated electrodes to the test in the brains of live rats.

In the meantime, there will be no lack of starting materials to carry out the next stages of the project, for the entire lab seems to love their brew. “The grad students provided quite a bit of coffee grounds — more than we will ever need,” says Ross. “My entire lab really loved this project.”

The researchers acknowledge support and funding from the National Institutes of Health and the National Science Foundation.

A recorded media briefing on this topic will be posted Monday, March 21, by 10 a.m. Eastern time at

ACS Spring 2022 will be a vaccination-required and mask-recommended event for all attendees, exhibitors, vendors, and ACS staff who plan to participate in-person in San Diego, CA. For detailed information about the requirement and all ACS safety measures, please visit the ACS website.

The American Chemical Society (ACS) is a nonprofit organization chartered by the U.S. Congress. ACS’ mission is to advance the broader chemistry enterprise and its practitioners for the benefit of Earth and all its people. The Society is a global leader in promoting excellence in science education and providing access to chemistry-related information and research through its multiple research solutions, peer-reviewed journals, scientific conferences, eBooks and weekly news periodical Chemical & Engineering News. ACS journals are among the most cited, most trusted and most read within the scientific literature; however, ACS itself does not conduct chemical research. As a leader in scientific information solutions, its CAS division partners with global innovators to accelerate breakthroughs by curating, connecting and analyzing the world’s scientific knowledge. ACS’ main offices are in Washington, D.C., and Columbus, Ohio.

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Deriving porous carbon from waste coffee grounds for sensitive dopamine detection with fast-scan cyclic voltammetry

Neurotransmitters are chemical messengers released from nerve terminals between neuronal synapses to regulate brain function. Although very important, neurotransmission occurs in extremely low molar concentrations and are quite difficult to detect in-vivo. Fast-scan cyclic voltammetry (FSCV) is an electrochemical technique which enables real-time detection of neurotransmitters at carbon fiber microelectrodes in the brain. Despite its utility, sensitive detection of low molar fluctuations in the brain remains difficult. Here, we are developing a carbon fiber modification method which uses porous carbon material made from waste coffee grounds for sensitive dopamine detection. Porous carbon material was obtained from waste coffee grounds by drying the grounds, heating them in a tube furnace at 700°C, mixing the material with KOH, and reheating the mixture in the tube furnace with nitrogen gas. A solution containing 2 mg/mL porous carbon material was dissolved in water and dip coated onto the carbon fiber. The oxidative current was compared before and after electrode modification. Overall, we demonstrate the use and synthesis of porous carbon material from waste coffee grounds to improve the sensitivity, limits of detection, and electron transfer rate for catecholamine detection with FSCV.

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