News Release

Osmotic pressure and viscosity: anticancer drug efficacy and restricting tumors using LDDS

Peer-Reviewed Publication

Tohoku University

Figure 1

image: This shows the improvement of drug delivery of anticancer drugs by expansion of lymphatic sinus with high osmotic and high viscosity solvents from A to H. view more 

Credit: Tohoku University

Cancer often transfers from its primary lesion to other lesions - clinically referred to as metastasis. In early metastasis, cancer cells invade lymphatic vessels, reach lymph nodes, and proliferate. Conventional chemotherapy for metastatic lymph nodes has limitations because only part of anticancer drug administrated by intravenous injection reaches the metastatic lymph nodes, and the expanded tumors restrict the bloodstream, preventing anticancer drug delivery.

The lymphatic drug delivery system (LDDS) provides an alternative strategy to conventional chemotherapy. Anticancer drugs are injected directly into sentinel lymph nodes under ultrasound guidance. LDDS is also available during intra-operative or image-guided surgery.

Professor Tetsuya Kodama and assistant professor Ariunbuyan Sukhbaatar of the Tohoku University Graduate School of Medical Engineering investigated the effect of osmotic pressure and the viscosity of anticancer drugs on the efficacy of lymph node metastasis treatment in collaboration with Dr Shiro Mori of Tohoku University Hospital. The authors found that optimal osmotic pressure and viscosity ranges significantly improved an antitumor effect.

This improvement could be explained as follows: the hyperosmotic fluid injected into the tumor-draining lymph nodes may increase the inflow of liquid components from blood vessels and high endothelial venules. Anticancer drugs with higher osmotic fluid could also flow in the efferent lymphatic vessels and the case expansion of lymphatic channels and vessels, allowing anticancer drugs to target tumor cells (Figure 1). Moreover, the optimized anticancer drugs of LDDS could target not only sentinel lymph nodes but also downstream lymph nodes with a high risk of secondary metastasis.

In summary, treatment using LDDS optimizes the physical properties of anticancer drugs, osmotic pressure and viscosity; improves the treatment efficacy; and restricts the spread of tumors in lymph node metastasis. It is anticipated these optimal ranges will be a starting point for developing more effective drug regimens to treat metastatic lymph nodes with the LDDS.

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