The book “Mixed Polymeric Micelles for Osteosarcoma Therapy” starts with an updated and concise guide to the pathophysiology of the disease, while also introducing the reader to new therapies and materials (specifically chitosan, polyethyleneimine, poloxamers, poloxamines, and Pluronics & reg;) used in the treatment process along with the aims of the experiments present subsequently. Next, the book documents the materials and methods used in developing polymeric micelles for delivering drugs to osteosarcoma sites. By explaining the basics of nanomedicine as a starting point, readers will understand how polymeric micelles act as facilitators of drug transport to cancer cells, and how one can synthesize a small stable micelle (by creating derivatives of base nanomaterials), capable of actively targeting osteosarcoma cells and overcoming multi-drug resistance. The chapter explains the synthesis and characterization techniques of the materials used to develop polymeric micelles. The results, a reflection of the conjugation of different experimental solutions initiated here, point to a modern route towards the search for a therapeutic solution for osteosarcoma. The simple, structured presentation coupled with relevant information on the subject of micelle-based nanotherapeutic drug delivery make this monograph an essential handbook for pharmaceutical scientists involved in the field of nanomedicine, drug delivery, cancer therapy and any researchers assisting specialists in clinical oncology for the treatment of osteosarcoma.
About the Author:
Professor Ana Rita Figueiras has obtained her Ph.D degree from the University of Coimbra, and is Researcher and Assistant Professor in the Faculty of Pharmacy in this institution. Actually, Ana Figueiras is scientific member of REQUIMTE/LAQV. Her research areas are polymeric micelles, cyclodextrins and mucoadhesive polymers in drug delivery. During her Ph.D. thesis she acquired experience in drug permeability, cellular viability and cytotoxicity studies, mucoadhesive biomaterials, therapeutic applications of cyclodextrins and computational studies in drug design. Now, her objective is to combine know-how development during her Ph.D thesis and new strategies for successful drug delivery, especially in what concerns the use of block copolymers and micellar systems. She has numerous scientific publications in prestigious journals, several book chapters and various communications in international conferences.
Keywords:
Nanotechnology, Polymeric micelles, Drug delivery, Gene delivery, Cancer therapy, Osteosarcoma, Block copolymers, Pluronics, Polyethyleneimine, Chitosan
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