Acta Pharmaceutica Sinica B Volume 13, Issue 1 publishes

https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/13/issue/1

Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Articles of interest in this issue include:

 

Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients by Solène Marie, Kayla L. Frost, Raymond K. Hau et al. (https://doi.org/10.1016/j.apsb.2022.08.018). Expression of several hepatic metabolizing enzymes and drug transporters are altered in NASH patients. Therefore, this review identifies drugs that may exhibit disrupted pharmacokinetics based on their ADME properties.

 

Kinome-wide polypharmacology profiling of small molecules by multi-task graph isomorphism network approach by Lingjie Bao, Zhe Wang, Zhenxing Wu et al. (https://doi.org/10.1016/j.apsb.2022.05.004). A multi-task graph isomorphism network model and related online web server were developed to predict the kinome-wide polypharmacology effects of small molecules with high accuracy.

 

Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation by Zhaodi Che, Yali Song, Chengfang Xu  et al. (https://doi.org/10.1016/j.apsb.2022.06.015). Melatonin alleviates ethanol-induced liver steatosis, cell death, and inflammation through a direct binding and regulation of hepatocyte surface EGFR, to inhibit nuclear BRG1 expression and enhance downstream TERT activity.

 

Other articles include:

 

Review Articles

Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies

Panat Yanpiset, Chayodom Maneechote, Sirawit Sriwichaiin, Natthaphat Siri-Angkul, ... Nipon Chattipakorn

 

Original Articles

CYP1B1-derived epoxides modulate the TRPA1 channel in chronic pain

Lili Sun, Jie Zhang, Changshan Niu, Cassandra E. Deering-

 

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, ... José Miguel Vela

 

Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS

Xunxun Wu, Lian Liu, Qiuling Zheng, Hui Ye, ... Ping Li

 

Renewal of embryonic and neonatal-derived cardiac-resident macrophages in response to environmental cues abrogated their potential to promote cardiomyocyte proliferation via Jagged-1–Notch1

Rong Chen, Shiqing Zhang, Fang Liu, Lin Xia, ... Zhaoliang Su

 

Targeting macrophagic 17β-HSD7 by fenretinide for the treatment of nonalcoholic fatty liver disease

Xiaoyu Dong, Yiting Feng, Dongqin Xu, Mengya Zhang, ... Jie Ping

 

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism

Mingming Sun, Leilei Li, Yujia Niu, Yingzhi Wang, ... Changliang Shan

 

Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virus-induced oxidative stress

Eun-Bin Kwon, Wei Li, Young Soo Kim, Buyun Kim, ... Jang-Gi Choi

 

Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

Yubi Lin, Ruonan Liu, Yanling Huang, Zhe Yang, ... Geyang Xu

 

Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity

Benjamin L. Prather, Shuyue Ji, Yue Zhao, Femil Joseph Shajan, ... Rongsheng E. Wang

 

Structure–activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M₄

Ahmed Haider, Xiaoyun Deng, Olivia Mastromihalis, Stefanie K. Pfister, ... Steven H. Liang

 

Bile duct ligation differently regulates protein expressions of organic cation transporters in intestine, liver and kidney of rats through activation of farnesoid X receptor by cholate and bilirubin

Shijin Hong, Shuai Li, Xiaoyan Meng, Ping Li, ... Li Liu

 

Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C-glycoside cleaving enzyme and an O- to C-glycoside isomerase

Pengfei He, Sha Wang, Sen Li, Siqi Liu, ... Wenfu Ma

 

Late-stage cascade of oxidation reactions during the biosynthesis of oxalicine B in Penicillium oxalicum

Tao Zhang, Guowei Gu, Guodong Liu, Jinhua Su, ... Liyan Yu

 

Functional characterization of a cycloartenol synthase and four glycosyltransferases in the biosynthesis of cycloastragenol-type astragalosides from Astragalus membranaceus

Yangyang Duan, Wenyu Du, Zhijun Song, Ridao Chen, ... Jungui Dai

 

Bilayer hydrogel dressing with lysozyme-enhanced photothermal therapy for biofilm eradication and accelerated chronic wound repair

Yizhen Wang, Qijun Lv, You Chen, Langtao Xu, ... Bo Liu

 

A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy

Yongchao Chu, Yifan Luo, Boyu Su, Chao Li, ... Tao Sun

 

Predatory bacterial hydrogels for topical treatment of infected wounds

Yan Liu, Bo Zhuang, Bochuan Yuan, Hui Zhang, ... Yiguang Jin

 

Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy

Zimo Liu, Xuefei Zhou, Qi Li, Youqing Shen, ... Xiangrui Liu

 

Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency

Li Yang, Qingyun Liu, Xinhui Wang, Nansha Gao, ... Xiaowei Zeng

 

All-stage targeted therapy for the brain metastasis from triple-negative breast cancer

Zimiao Luo, Sunyi Wu, Jianfen Zhou, Weixia Xu, ... Weiyue Lu

 

Highly sensitive H₂O₂-scavenging nano-bionic system for precise treatment of atherosclerosis

Xiaoyu Liang, Huiyang Li, Xuanling Li, Xinxin Tian, ... Jing Yang

 

Pathologically triggered in situ aggregation of nanoparticles for inflammation-targeting amplification and therapeutic potentiation

Qiang Nie, Chenwen Li, Yu Wang, Yi Hu, ... Jianxiang Zhang

 

Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing

Hangyi Wu, Pei Yang, Aiqin Li, Xin Jin, ... HuiXia Lv

 

Sialic acid-mediated photochemotherapy enhances infiltration of CD8⁺ T cells from tumor-draining lymph nodes into tumors of immunosenescent mice

Dezhi Sui, Changzhi Li, Xueying Tang, Xianmin Meng, ... Yanzhi Song

 

Letter to the editor

Rational design and crystallographic analysis of novel isoform-selective TRKA inhibitors for cancer therapy

Guan Wang, Yongya Wu, Chengyong Wu, Wen Shuai, ... Liang Ouyang

 

# # # # # #

The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 15.9

Impact Factor: 14.903

JIF without self-citation: 13.888

 

ISSN 2211-3835

 # # # # #

 

---

---