A team led by Academician Ge Junbo and Professor Sun Aijun at Fudan University reveals that environmental eustress attenuates doxorubicin-induced cardiotoxicity while enhancing antitumor effects via a hypothalamus-heart-tumor axis. Eustress upregulates hypothalamic BDNF, which activates TrkB receptors on cardiac resident macrophages to inhibit CCL2 secretion, thereby reducing pro-inflammatory Ly6C^high monocyte/macrophage infiltration into heart tissue. In hepatocellular carcinoma models, eustress also downregulates tumor microenvironment CCL2, decreasing immunosuppressive G-MDSCs and M2 macrophages while increasing cytotoxic CD8+ T cells and M1 macrophages. CCL2 is identified as a core dual target for cardio-oncology intervention, providing a safe and accessible non-pharmacological strategy for preventing chemotherapy-related cardiac toxicity in cancer patients.

Eye AI is moving fast, but will it work for people living at high altitude? In a study accepted by Science Bulletin, Dr. Wu Yuan’s team found that leading ophthalmic foundation models can lose accuracy across high-altitude retinal image cohorts. The team developed MIXFound, a lightweight way to combine several models and make AI diagnosis more robust in underrepresented settings.

A research team led by Professors Weiwei Jin and Wei Huang from China Agricultural University, in collaboration with Tianjin Agricultural University and the University of São Paulo in Brazil, elucidated how two anther-specific plasma membrane hexose transporters, ZmSWEET6a and ZmSWEET6b, coordinately regulate pollen wall development and cellular homeostasis. The study has been published online in The Crop Journal.

Herein, we report a user-friendly electrocatalytic glycosylation strategy that employs stable and readily available acetyl glycosides as glycosyl donors. The reaction proceeds at room temperature and ambient pressure in an undivided electrolytic cell, enabling rapid access to structurally diverse O‑, S‑, and N‑glycosides, as well as disaccharides, with moderate to excellent diastereoselectivity. The lithium perchlorate/acetonitrile electrolyte system was identified as the optimal reaction medium. Mechanistic studies reveal that a Brønsted acid generated in situ at the anode activates the C–O bond of the acetyl glycosides, thereby initiating the glycosylation process. This method features exceptionally broad substrate scope, excellent functional group tolerance, requires only a catalytic amount of charge (0.1 F/mol), and reaches completion within 10 minutes.