Researchers have built the first photonic computing chip that simultaneously exploits 32 wavelengths, 3 spatial modes, and 2 polarizations—192 parallel channels in total. The chip supports dynamically reconfigurable convolution kernels up to 13×13, enabling multi‑scale feature extraction and structured noise suppression. It achieves an experimental throughput of 15.36 TOPS, paving the way for high‑precision optical AI in computer vision and biomedical imaging.

Autophagy plays a cell-specific, bidirectional role in neuropathic pain-protective in some contexts but potentially detrimental in others. This review maps the complex regulatory network across neurons, astrocytes, and microglia, and critically evaluates therapeutic strategies targeting this cellular process, offering a roadmap for developing precision treatments.

Homeostatic Medicine, as an emerging integrative discipline, is driving a profound shift in medical paradigms from the traditional "eradication of pathogenic factors" to the "restoration of inherent homeostasis" by decoding the core mechanisms of the body's self-regulation. This discipline redefines the essence of health and disease, offering a novel theoretical framework and clinical intervention strategies for disease prevention and treatment.

Researchers from Chongqing Medical University discovered that excessive fibrin deposition drives chronic gum inflammation in diabetes by disrupting immune-epithelial crosstalk. By utilizing an engineered peptide (377P) to block fibrin-macrophage interactions, the team successfully suppressed inflammation, restored the mucosal barrier, and promoted alveolar bone healing in diabetic mice. This study identifies fibrin as a druggable target for diabetic periodontitis and potentially other systemic diabetic complications.

Nanomedicines often acquire a protein corona in the bloodstream before reaching the brain. A new Perspective in Science Bulletin argues that this evolving layer should be engineered as a programmable interface that can guide recognition, transcytosis and release across the blood-brain barrier.