Neutrophils are the body’s first line of defense against infection. But if too many attack for too long, they can damage the tissues they’re meant to protect. In the lungs, this damage can lead to acute respiratory distress syndrome, the leading cause of death due to COVID-19. CSHL researchers have found that using a drug to inhibit a protein called PTP1B can prevent lethal lung inflammation in mice. This discovery may lead to better treatments for severe inflammatory conditions like sepsis and COVID-19.
- JCI Insight
- NIH/National Institutes of Health, Achelis and Bodman Foundation, Don Monti Memorial Research Foundation, Hansen Foundation, Pershing Square Foundation, William C. and Joyce C. O’Neil Charitable Trust, Cancer Research Institute, Robertson Research Fund