Some 33 million Americans have severe food allergies. Now, researchers at Boston Children’s Hospital may have found a promising solution. In a small clinical trial, Rima Rachid, MD, director of the Food Allergy Program and the Allergen Immunotherapy Program, and Talal Chatila, MD, director of translational immunology, and their colleagues found that some participants with peanut allergies experienced a higher tolerance to peanuts months after receiving a fecal transplant from a healthy donor without food allergies. Their findings are published today in Science Translational Medicine.

When people encounter new information that challenges their expectations, their pupils are likely to dilate. This physiological response is a sign that something is happening in the brain to help the person adapt to the new situation, according to a study led by Brown University researchers and published in Nature Human Behaviour.

DepMap scientists have generated dependency data on nearly 150 three-dimensional cancer cell models across 10 cancer types.

The updated catalog reveals cancer phenotypes, cell states, and gene dependencies  that are missed in traditional cell lines and shows that both model types are complementary because each captures biology that the other misses.

The integration of data on 2D and 3D models creates a more comprehensive DepMap, moving the resource towards its goal of capturing the complete landscape of cancer vulnerabilities.