When people encounter new information that challenges their expectations, their pupils are likely to dilate. This physiological response is a sign that something is happening in the brain to help the person adapt to the new situation, according to a study led by Brown University researchers and published in Nature Human Behaviour.

DepMap scientists have generated dependency data on nearly 150 three-dimensional cancer cell models across 10 cancer types.

The updated catalog reveals cancer phenotypes, cell states, and gene dependencies  that are missed in traditional cell lines and shows that both model types are complementary because each captures biology that the other misses.

The integration of data on 2D and 3D models creates a more comprehensive DepMap, moving the resource towards its goal of capturing the complete landscape of cancer vulnerabilities.