Voice experiments in people with epilepsy have helped trace the circuit of electrical signals in the brain that allow its hearing center to sort out background sounds from their own voices. 

A series of five papers, published today in The Lancet Oncology by a University of Pittsburgh-led international team, highlights critical public health challenges related to cancer control in the eight countries that form the South Asian Association for Regional Cooperation (SAARC) and the Rohingya refugee population in Bangladesh. The series underscores barriers contributing to significant disparities in cancer outcomes and identifies actionable solutions to address these challenges in one of the most comprehensive efforts to understand this region’s cancer burden.  

A critical review of cell-based and cell product-based therapies for the treatment of heart failure details 20 years of completed and ongoing clinical trials. While none has yet gained medical approval, pathways to new treatments for heart failure can take decades, as seen for two other, now accepted therapies.

Ketone bodies are not just about energy. These metabolites are powerful signaling molecules that have profound effects on the proteome and protein quality control in the brain.  Publishing in Cell Chemical Biology Buck Institute scientists, working in mouse models of Alzheimer’s disease and aging, and in the nematode C. elegans, reveal the ketone body β-hydroxybutyrate interacts directly with misfolded proteins, altering their solubility and structure so they can be cleared from the brain through the process of autophagy. The work hints at a tantalizing possibility – ketone bodies as a global treatment to restore the integrity of the proteome, addressing one of the key hallmarks of aging.