Johns Hopkins Medicine researchers say they have identified molecular pathways controlled by the protein RhoA in club cells — a specialized population of epithelial cells that exclusively lines the inner and outer surfaces of the lung’s small airways, with known roles in immune regulation and airway repair — during allergen-induced airway inflammation. Through a series of translational mouse and cell culture experiments, the research team has demonstrated how RhoA can be selectively targeted to potentially prevent asthma-related complications. 

In their validation study, they showed that individuals with high genetic risk scores had significantly greater odds of developing disease compared to those with average risk.

Most people strongly support the federal government’s reclassification of cannabis, according to a new study that used AI to analyze more than 40,000 comments in the public record.

The findings by researchers at Johns Hopkins University and the University of California San Diego, which come as the Trump administration last week reclassified state-licensed medical marijuana from a Schedule I drug to a less dangerous Schedule III, suggest the public would like to see even more reform.

A new study by researchers at the Icahn School of Medicine at Mount Sinai overturns a longstanding assumption about how mRNA vaccines generate immunity, revealing that certain non-immune cells help determine vaccine effectiveness. The study, published in the April 29, 2026 online issue of Nature Biotechnology https://doi.org/10.1038/s41587-026-03099-z], also introduces a powerful and versatile technology to control the expression of mRNA drugs, which the researchers demonstrate can enhance the effectiveness of mRNA cancer vaccines in preclinical studies of lymphoma. The findings provide a new framework for designing mRNA vaccines and mRNA therapeutics, with immediate implications for cancer immunotherapy, infectious disease vaccines, and gene-editing treatments.