New CRISPR technique could rewrite future of genetic disease treatment
Peer-Reviewed Publication
Updates every hour. Last Updated: 10-Sep-2025 13:11 ET (10-Sep-2025 17:11 GMT/UTC)
Shedding light on what determines how cells become what they are meant to be—nerves, bone, muscles, etc.—can also help researchers understand how diseases develop when these biological programs break down.
Now, researchers at Case Western Reserve University have discovered a key synergistic role for two epigenetic markers—molecules that help tell genes to turn on and off—involved in programming cell fate. Importantly, turning off these two markers causes genes to over-activate, disrupting normal cell development.A new study will investigate whether levels of the lung protein CC16 in childhood can predict risk of early chronic obstructive pulmonary disease later in life.