The secret to antibody diversity lies in DNA loops
Peer-Reviewed Publication
Updates every hour. Last Updated: 25-Jun-2026 12:15 ET (25-Jun-2026 16:15 GMT/UTC)
How does your body produce millions of antibodies from one genome? New research reveals how two closely-related proteins help immune cells fold DNA, connecting distant genetic pieces to create diverse antibodies that help fend off disease. In a new Nature Communications paper, a Michigan State University team discovered that the chromosome-organizing proteins STAG1 and STAG2 play distinct roles during antibody-gene assembly.
A team of scientists from the Barbara Ann Karmanos Cancer Institute, Wayne State University, and institutions across the U.S., have published a landmark paper on the role of TGFBR1*6A, a naturally occurring genetic mutation in the TGFBR1 gene found in approximately 14 percent of the general population.
Wildfire smoke can trigger breathing problems and flare-ups for people with chronic obstructive pulmonary disease (COPD), yet many people are not receiving the trusted health information they need to stay safe, according to a new study in the May 2026 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open access journal.
Reported June 23 in Nature Biomedical Engineering, researchers at Vanderbilt Health and centers in Hong Kong have created a versatile uncertainty-aware AI framework broadly adaptable as a wrapper for digital pathology AI systems. (An AI wrapper acts as an interface layer that customizes, formats and automates how users interact with the underlying intelligence.) They demonstrate their wrapper, called TRUECAM, primarily with reference to non-small cell lung cancer (NSCLC) subtyping using whole-slide images.
In a novel experiment at the University of Cincinnati, researchers isolated kissing bugs, fruit flies, mosquitoes and spider beetles in a climate- and light-controlled environment and found that they responded predictably to cycles of humidity in the same way they do temperature and daylight. After the humidity cue was removed, the insects continued to respond to the cyclical fluctuations of humidity and dryness established in the experiment.