Depression stalls formation of new brain cells
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Oct-2026 04:17 ET (29-Oct-2026 08:17 GMT/UTC)
Japan has one of the world’s longest-living populations, yet predicting which octogenarians will lose their independence remains difficult. Now, researchers identify two blood proteins—beta-2-microglobulin and cystatin C—that are consistently associated with future disability in adults aged 85 years and older. The findings, independently replicated in an Italian aging cohort, suggest that kidney dysfunction and chronic inflammation contribute to disability risk and could support earlier preventive interventions in rapidly aging populations worldwide.