Researchers at the University of Pennsylvania and international collaborators have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis. “Although TRIM can have beneficial effects—protecting against infections and cancer—the memory of a previous infection may also contribute to inflammatory diseases and the comorbidity between inflammatory bone loss disorders,” says George Hajishengallis of Penn Dental Medicine.

Scientists at VCU Massey Comprehensive Cancer Center have identified an innovative combination of treatment strategies that work collaboratively to effectively kill acute myeloid leukemia (AML) cells, a frequently incurable form of cancer. New research findings — published in the Nature family journal Signal Transduction and Targeted Therapy — suggest that a class of drugs known as MCL-1 (myeloid leukemia cell-1) inhibitors interact with a type of kinase inhibitor that targets the SRC gene to efficiently trigger cell death in AML cells.