circTP63-N抑制鼻咽癌恶性表型的模式图 (IMAGE)

Science China Press

circTP63-N抑制鼻咽癌恶性表型的模式图

Caption

环状RNA circTP63-N通过与HSP90AB1蛋白直接结合，促进LATS1/2激酶的募集和活化，从而诱导YAP1的磷酸化与泛素化降解，阻止其核转位。由此抑制了YAP1对下游靶基因（INHBA、MMP3和CCNE2）的转录激活，最终抑制鼻咽癌细胞的增殖、侵袭及转移能力。

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©《中国科学》杂志社

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