NKAPL suppressed NSCLC growth and metastasis in vivo. (IMAGE)
Caption
(A) A549 cells stably expressing the vector and NKAPL-GFP were subcutaneously injected into BALB/c nude mice. Images of the subcutaneous tumors of the nude mice were captured. (B, C) The volume of the subcutaneous tumors in the nude mice was measured, and the tumors were weighed. (D) Hematoxylin-eosin staining and the expression changes of NKAPL and Ki-67 in xenograft tumors were examined by immunohistochemistry staining. (E, F) Representative bioluminescence images of the metastatic mouse models at the indicated times imaged by an in vivo imaging system. (G) Hematoxylin-eosin-stained sections showed pulmonary metastatic foci indicating A549-Luc cells in lung tissue sections. The data were presented as mean ± standard deviation (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001.
Credit
Genes & Diseases
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