Aneuploidy of the MHC region revealed through assembled haplotypes of cell lines. (IMAGE)
Caption
(A–D) Aneuploidy in the A549 (A), K562 (B), U2OS (C), and HepG2 (D) cell lines were visualized using the log2 transformed sequencing depth ratio between the two assembled MHC haplotypes. Orange lines represent the results smoothed over a 10 kb window. Dotted lines indicate the overall ratios between two haplotypes, with the values shown on the left. Blue boxes represent regions corresponding to three HLA class I genes (HLA-A, HLA-B, and HLA-C), C4 genes, and three HLA class II genes (HLA-DR, HLA-DQ, and HLA-DP).
Credit
Haozhe Yuan, Mengping Jiang, Xingyu Xu, Jialiang Zhu, Shulong Dong, Weida Meng, Dandan Zhang, Jiakang Ma, Yicheng Lin, Ziqiang Chen, Shaoyang Sun, Wenqing Qiu, Yun Liu
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND