RAB26 promotes epithelial–mesenchymal transition and stem cell-like characteristics of prostate cancer cells. (IMAGE)
Caption
(A, B) The results of GSEA enrichment analysis and representative GSEA data. (C, D) Western blotting and quantitative reverse-transcription PCR detected the expression of epithelial-mesenchymal transition-related marker proteins in PC3, LNCaP, and 22RV1 cells. (E) The relationship between RAB26 and mRNA score. (F) Quantitative reverse-transcription PCR detected the expression of stem cell-related markers in PC3, LNCaP, and 22RV1 cells. (G) RAB26 affected the formation of tumor stem cell spheres in PC3, LNCaP, and 22RV1 cells. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001.
Credit
Hexi Wang, Simin Liang, Xiaoyi Du, Guozhi Zhao, Yuanyuan Bai, Junwu Li, Haoyu Xu, Senlin Peng, Ye Yuan, Wei Tang
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