OGT Promotes MASLD-Related Liver Cancer by Driving PTEN Degradation (IMAGE)

Sichuan International Medical Exchange and Promotion Association

OGT Promotes MASLD-Related Liver Cancer by Driving PTEN Degradation

Caption

A lipid-rich and hypoxia tumor microenvironment elevates O-GlcNAc transferase (OGT) expression, catalyzing O-GlcNAcylation of the tumor suppressor PTEN. Specifically, O-GlcNAcylation of PTEN in T382 blocks phosphorylation at the same residue, promoting PTEN ubiquitination and degradation. This disruption of PTEN contributes to the progression of hepatocellular carcinoma (HCC).

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Jianming Li

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