LRRC8A plays an important role in neurological diseases (IMAGE)
Caption
(A) Astrocytes can release glutamate through LRRC8A/VRAC to increase neuronal excitability, thereby increasing the risk of epileptic seizures. (B) LRRC8A exacerbates stroke by promoting neuronal cell death, VSMC proliferation, and vascular remodeling; decreasing phagocytosis and hematoma clearance. NMDAR, N-methyl-d-aspartate receptor; AMPAR, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; VSMC, vascular smooth muscle cell
Credit
Longjun Yang, Qiang Ding, Xiaoyu Ji, Panpan Lu, Mei Liu
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CC BY-NC-ND