Xbp1s expression was up-regulated during the process of cardiac fibrosis (IMAGE)

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Xbp1s expression was up-regulated during the process of cardiac fibrosis

Caption

(A) Relative mRNA levels of fibrotic markers in angiotensin II (Ang II)-infused hearts (n = 6 for each time point). (B) Transcription of UPR genes was induced in Ang II-infused hearts (n = 6 for each time point). (C) Xbp1s protein expression was increased in Ang II-infused hearts (n = 6). PCNA was used as a loading control for nuclear extracts. (D) Transcription of UPR genes was increased after pressure overload (n = 6 for each time point). (E) Xbp1s protein expression was increased after pressure overload for 4 weeks (n = 6). Data are shown as mean ± standard error of the mean, and analyzed using an unpaired two-tailed Student′s t-test. ∗P < 0.05.

Credit

Yiming Dong, Hongyu Su, Peipei Zheng, Zekai Tao, Zhengyu Chen, Peiheng Han, Li Zhang, Yuan Liu

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