LV-Xbp1s-mir1/133TS rescued Ang II-induced cardiac remodeling in Xbp1s mfKO mice (IMAGE)
Caption
(A) Xbp1 mfKO mice were injected with LV-Con-mir1/133TS, LV-Xbp1u-mir1/133TS, or LV-Xbp1s-mir1/133TS, followed by Ang II infusion for 4 weeks. Xbp1s protein expression was assessed in the heart. (B) Cross-sectional area as detected by wheat germ agglutinin staining in Xbp1 mfKO receiving LV-Xbp1s-mir1/133TS after Ang II infusion (n = 6). (C) Fibrosis area as detected by picrosirius red in Xbp1s mfKO receiving LV-Xbp1s-mir1/133TS after Ang II infusion (n = 6). (D) Ejection fraction (EF) was detected in these groups (n = 6). The data were compared by one-way ANOVA. Data are shown as mean ± standard error of the mean, and analyzed using one-way ANOVA followed by Tukey post hoc test. ∗P < 0.05 versus the matched control.
Credit
Yiming Dong, Hongyu Su, Peipei Zheng, Zekai Tao, Zhengyu Chen, Peiheng Han, Li Zhang, Yuan Liu
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