psiTPTE22-HERV suppressed subcutaneous tumor growth and metastasis in vivo (IMAGE)
Caption
(A) Reduced subcutaneous tumor growth in nude mice with psiTPTE22-HERV-transfected cells versus controls in terms of tumor volume (A1) and tumor weight (A2). (B) psiTPTE22-HERV expression in xenografts confirmed by immunostaining. (C) Decreased proliferation in psiTPTE22-HERV-expressing tumors indicated by Ki-67 staining. (D) Increased apoptosis in psiTPTE22-HERV-expressing tumors revealed by TUNEL staining. (E) Reduced liver and lung metastasis shown by representative macroscopic images (E1) and hematoxylin-eosin staining (E2). The data were presented as mean ± standard error of the mean (A1, A2, E2) or mean ± standard deviation (B–D) and compared using two-way ANOVA (A1), unpaired t-test (A2, B–D), chi-square test, or Mann–Whitney U test (E2).
Credit
Fei Xu, Mengwen Zhang, Suzhan Zhang, Yao Zeng, Shu Zheng, Jessie Qiaoyi Liang
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND