Mechanisms of radiation resistance acquisition in oral cancer cells. (IMAGE)

Kumamoto University

Mechanisms of radiation resistance acquisition in oral cancer cells.

Caption

Extracellular vesicles released from radiation-resistant oral cancer cells are taken up by radiation-sensitive cells, which release miR-503-3p. The released miR-503-3p suppresses BAK, a protein that promotes apoptosis, thereby preventing radiation-induced cell death (apoptosis). As a result, radiation-sensitive cells acquire radioresistant.

Credit

From Fig. 6E of Yamana K., et.al., Journal of Extracellular Vesicles, 2021. The image has been modified for use and clarity within this release.

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CC BY-NC

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