Powering forward: A year of discovery in mitochondrial science

Mitochondria are the powerhouses of the cell and also a key factor in unraveling life processes and disease mechanisms. As a platform featuring cutting-edge perspectives in mitochondrial biology, Mitochondrial Communications is committed to advancing interdisciplinary research oriented toward mitochondrial health, with the aim of rapidly publishing high-quality, rigorously peer-reviewed research articles, reviews, and commentaries.

We are pleased to share with you the latest research findings in the field of mitochondrial biology, calcium signaling emerged as a central theme.

Decoding the influence of mitochondrial Ca²⁺ regulation on neurodegenerative disease progression

Jianxu Sun, Ge Gao, Sitong Wang, Hongmei Liu, Tie-Shan Tang

Are patients with mitochondrial diseases prone to inflammatory and immune dysfunction: A scoping review and retrospective chart analysis

Eiti Rautela, Savannah Sauve, Nikki Kovac, Edana Cassol, David Dyment, Martin Holcik

Mitochondrial‐derived vesicles: at the crossroads of mitochondrial functions and metabolites

Min Tang, Zhiyin Song, Da Jia

Extra-mitochondrial ATP synthesis, proton dynamics at the membrane, and mitochondria-derived vesicles: Current findings and considerations

Alessandro Maria Morelli, Ann Saada, Felix Scholkmann

Mitochondrial heterogeneity: within and between cells

Shiyuan Chen, Jiangbin Ye, Zhenglong Gu

In vivo imaging of neuronal mitochondrial Ca²⁺ transients with two-photon microscopy in awake mice

Shan Qiu, Haoyu Zhang, Fangxu Zhou, Haipeng Huang, Heping Cheng, Xianhua Wang

Age-related dynamics of m.189A>G and m.408T>A variants in skeletal muscle of an osteoarthritic Cohort: Connections to BMI and muscle strength

Valeria Lobanova, Ivan Kozenkov, Eldar Khaibulin, Maria Tatarkina, Bogdan Efimenko, Viktoria Skripskaya, Akhsarbek H. Dzhigkaev, Anastasia S. Krylova, Anastasia V. Prokopenko, Stepan V. Toshchakov, Andrey Goncharov, Konstantin Popadin, Konstantin V. Gunbin

Frontiers in LONP1 research: Unraveling molecular mechanisms, disease associations, and therapeutic strategies

Wenwen Xi, Zhiyan Zhang, Yi Su, Shuyi Wang, Yangzheng Ou, Bin Lu

PINK1-Parkin-mediated regulation of mitochondrial dynamics: A core function parallel to mitophagy control

Hui Jiang

Mitochondrial dynamic changes and energy surplus

Kaiyue Wu, Shuang Shen

Nucleotide imbalance fuels ageing-associated inflammation

Tao Long, Da Jia, Lin Zhao

Off-target effects of mitochondrial oxidative phosphorylation inhibitors are common and can compromise the viability of cultured cells

Natalya Kozhukhar, Mikhail F. Alexeyev

A chemical-genetic approach to target voltage-sensitive fluorophores to mitochondria

Julia G. Martin, Tong Zhan, Deshka L. Neill, Ke Xu, Evan W. Miller

The mitochondrion — once viewed simply as the cell's powerhouse — continues to reveal itself as a master regulator of cellular fate, a sentinel of metabolic stress, and a critical player in health and disease. The articles exemplify this expanded understanding, spanning from fundamental mechanisms of calcium signaling and energy metabolism to clinical manifestations in cancer, neurodegeneration, and aging.

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Contact the author: huanguo@keaipublishing.com

The publisher KeAi was established by Elsevier and China Science Publishing & Media Ltd to unfold quality research globally. In 2013, our focus shifted to open access publishing. We now proudly publish more than 200 world-class, open access, English language journals, spanning all scientific disciplines. Many of these are titles we publish in partnership with prestigious societies and academic institutions, such as the National Natural Science Foundation of China (NSFC).