Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in ACS Nano, how proteins in cells can be controllably activated through heating, an effect that can be used to initiate programmed cell death.

Associate Professor Yusuke Imoto at Kyoto University has developed iRECODE, a comprehensive computational method that removes noise from single-cell data, revealing the true activity of individual cells. By removing both technical noise and batch noise, iRECODE allows scientists to detect rare cell populations and subtle changes that were previously hidden, bringing single-cell analysis closer to telling the real story of each cell.

The research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ Immunology Frontier Research Center at The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease.

A team of scientists at Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS) has created a protein-based therapeutic tool  that could change the way we treat diseases caused by harmful or unnecessary cells. The new tool, published in Nature Biomedical Engineering, involves a synthetic protein called Crunch, short for Connector for Removal of Unwanted Cell Habitat. Crunch uses the body’s natural waste removal system to clear out specific target cells, offering hope for improved treatments for cancer, autoimmune diseases, and other diseases where harmful cells cause damage.