Genetic risk and lifestyle jointly influence upper gastrointestinal cancer risk in a Chinese endoscopy-screened cohort
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Updates every hour. Last Updated: 26-Oct-2026 11:16 ET (26-Oct-2026 15:16 GMT/UTC)
Researchers studying 5556 participants in a Chinese endoscopy-screened cohort found that genetic risk and lifestyle independently and jointly influenced upper gastrointestinal cancer risk. The study identified a potential new gastric cancer susceptibility locus at 6p12.1 from genome-wide association study and showed that adding polygenic risk scores to conventional risk models improved risk stratification. A healthy lifestyle reduced risk across genetic risk groups, with greater benefit among those at high genetic risk.
Brain-computer interfaces are moving beyond simple device control toward more dexterous robotic assistance. A new review highlights how noninvasive neural decoding, deep learning, and shared autonomy are helping robotic devices better interpret user intent, reduce control burden, and support future assistive technologies for people with motor impairments and the general population.
To overcome the challenges of low efficiency and high cost in plastic upcycling, a team from ICCAS has introduced a two-stage tandem catalytic strategy in Science Bulletin. This noble-metal-free process transforms polyethylene into aromatics with a high yield of 59.9%, providing a sustainable, low-cost solution for the valorization of plastic waste.
A stretchable, self-healing semiconductor has been developed using hierarchical hydrogen bonds—like mixing Velcro with a zipper. Unlike single-strength bonds, these multi-level bonds work together to balance rigidity and flexibility. It achieves 150% stretchability, 90% electrical healing, and record mobility of 1.01 cm² V⁻¹ s⁻¹ under 150% strain. This solves the trade-off between charge transport, stretchability, and healing ability, paving the way for future stretchable electronics.
Researchers from the group of Prof. Jia Shuang at Peking University and the group of Prof. Xu Gang at Huazhong University of Science and Technology have recently collaborated to investigate the heavy-fermion ferromagnet CeCrGe3. They observed giant anomalous Hall and anomalous Nernst effects and revealed that these remarkable responses originate from Kondo-driven topological flat bands. The results were published under the title “Giant Anomalous Hall and Nernst Effects in a Heavy Fermion Ferromagnet” in Science Bulletin.
The discovery of pathogenic genes based on large CHD cohort forms the foundation for improving early diagnosis, prevention, control, and treatment of CHD. To this end, Academician Lin He launched the Chinese Children's CHD Genome Research Project. The research team conducted whole-genome sequencing on 354 core CHD families from China, integrated single-cell transcriptomic data and phenotypic analysis in model animals, and identified high-confidence CHD risk genes. This study has constructed the largest genetic etiology map of congenital heart disease in Asian populations.
Recent advances in grayscale lithography have significantly expanded its capabilities for three-dimensional micro- and nanofabrication, offering distinct advantages over conventional binary lithography for the realization of complex integrated devices. This technology has enabled high-resolution 3D structuring in applications such as microlens arrays, blazed gratings, microfluidic systems, MEMS, and biomimetic interfaces. Nevertheless, existing methods remain fundamentally limited in vertical resolution—typically from the micrometer scale down to tens of nanometers—leaving grayscale patterning at the nanometric and even Ångström levels largely unexplored.
In this work, researchers report a probe-guided laser direct writing (PG-LDW) approach capable of fabricating multi-level step structures with step heights of ~2 Å. This resolution surpasses the current benchmark of 6 nm achieved by grayscale electron beam lithography, thereby breaking the long-standing resolution barrier. By employing probe-guided surface focusing in combination with laser power modulation, they achieve controlled material removal without photoresist masks or dry etching processes, thus eliminating contamination and etch-induced distortions. The process is performed under ambient conditions, allowing direct writing of complex patterns into 2D materials. The structural and chemical modifications were systematically characterized using in situ atomic force microscopy (AFM), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). Moreover, the integrated AFM capability of the probe further allows iterative multi-pass processing with real-time feedback and precise rewriting. This probe-guided laser lithography technique provides high-fidelity, sub-nanometer vertical-step resolution in a resist-free context, opening new opportunities for the down-scaling fabrication of next-generation nanophotonic, nanoelectronic, and biomimetic devices.