A Peking University team has automated cataract screening from routine IOL Master 700 scans. Their "lens average density" biomarker achieved an AUC of 0.975 and correlated strongly with the clinical LOCS III standard (ρ = 0.804). The study revealed that highly myopic eyes (axial length ≥26 mm) carry a distinct nuclear cataract signature—83% prevalence versus 40% in normal-length eyes—emerging roughly 12 years earlier. The approach could embed early screening into existing workflows without extra patient burden.

Cancer immunotherapy offers long-term remissions but struggles with primary resistance, complex progression, and severe side effects. A landmark review in Science Bulletin highlights how multimodal AI integrates multi-scale data—from spatial omics and pathology to imaging and health records—to transform patient stratification. Tracing AI's evolution into foundation models and "virtual cells," the authors outline a clinical roadmap balancing efficacy, toxicity, and disease dynamics.

A novel OsSBEIIb allele was identified in an indica rice mutant. The OsSBEIIb mutation increases the resistant starch (RS) content in raw rice flour, as well as in retrograded and heated rice. The chalk2 mutant serves as a valuable indica rice germplasm for breeding high-RS rice varieties.

An elite germplasm, G253, with superior morphogenic callus induction and proliferation capacity was identified. A stable Agrobacterium-mediated transformation platform enabling transgenic plant generation was established. An efficient protoplast transient transformation system was developed from the morphogenic callus.

Building upon their earlier platform Crop-GPA 1.0, a team of researchers in China developed Crop-GPA 2.0 to enable transferable SNP-level genotype–phenotype association prediction across crop species. Across multiple crop species, Crop-GPA 2.0 improved cross-species prediction performance, remained robust under limited training data, and identified biologically meaningful SNPs supported by previously reported quantitative trait locus (QTL) evidence.

Stem diameter is an important agronomic trait that affects lodging resistance and stem yield in flax. To clarify the genetic basis of stem diameter, a team of researchers from Xinjiang University, Xinjiang Normal University, and Xinjiang Academy of Agricultural and Reclamation Science conducted a multi-model genome-wide association study (GWAS) using 200 diverse flax accessions representing oil flax, fiber flax, and oil–fiber dual-purpose flax evaluated in three environments. The study provides genetic insights into the natural variation of flax stem diameter, identifying loci and genes as direct targets for molecular breeding to improve lodging resistance and stem yield.