A propensity score-matched cohort study compared kidney-sparing surgery with radical nephroureterectomy in patients with ureteral urothelial carcinoma. After matching, radical nephroureterectomy was associated with better overall and cancer-specific survival, especially in selected subgroups. The findings support refined risk stratification and careful patient selection

A study by researchers from the Department of Reproductive Medicine, Jinling Hospital Affiliated to Nanjing University, and Medical School of Nanjing University suggests that antibiotic residue-related exposure may impair spermatogenesis by disturbing mitochondrial function. The researchers further found that DHA, an omega-3 fatty acid, may help protect spermatocytes by restoring ER–mitochondria communication and reducing oxidative stress.

Not all lung cancers with the same common genetic driver respond equally to powerful targeted drugs. Researchers have now discovered why: subtle differences in the 3D shape of the mutated protein. By classifying these shapes, they identified a subtype that poorly binds to latest-generation drugs, explaining worse outcomes. The good news? Starting with a drug-chemo combo likely overcomes this resistance, offering a clear path to personalize first-line treatment.

Fear learning is a key adaptive mechanism, but its links to the immune system remain unclear, especially in people with childhood maltreatment. This study examined whether the type and timing of childhood abuse and neglect influence the relationship between brain function during fear learning and inflammation. Data were collected from 128 adults, including inflammatory markers (IL-8, IL-17) and fMRI brain scans during a fear conditioning task. Results revealed that the type and timing of childhood maltreatment differentially moderate associations between fear-related brain activity, functional connectivity, and inflammatory levels. These findings help explain how early adversity increases long-term health risks by altering neural-immune interactions.