Microscopy plays a pivotal role in modern biomedical research, enabling the visualization of fine structures in complex specimens. Fourier ptychographic microscopy (FPM) is a computational imaging technique that combines multi-angle illumination with numerical reconstruction to achieve both high resolution and a wide field of view on standard microscope hardware. However, for samples with thickness variation, tilt, or inherently three-dimensional structures, the limited depth of field means that only a narrow focal region appears sharp, while out-of-focus areas remain blurred. This fundamentally constrains the applicability of conventional FPM to real 3D biological specimens. To address this challenge, the authors propose an all-in-focus FPM framework that integrates three-dimensional implicit neural representations with a physics-based imaging model, enabling uniformly sharp reconstructions across the entire depth range and substantially improving the performance of downstream tasks such as image segmentation. This is particularly important for research that requires obtaining the full cell morphology, statistical feature distribution, or conducting large-scale cell behavior analysis. By significantly enhancing the usability of three-dimensional sample imaging, this method provides a more reliable image foundation for high-throughput cell phenotypic analysis, pathological screening, and other life science scenarios.

Recently, a research team led by Professor Xie Huiqi at Sichuan University conducted a systematic review of dual-function biomaterials that combine anti-tumor and bone regeneration capabilities for postoperative osteosarcoma treatment. The article categorizes existing research findings into three design strategies: conventional dual-function strategies, enhanced anti-tumor strategies, and temporally regulated strategies. It further explores their design principles, therapeutic efficacy, and potential for clinical translation. This review aims to provide insights for establishing an integrated "anti-tumor and bone regeneration" treatment model and offers perspectives on future research directions in the field. The related work, entitled "Dual-Function Biomaterials for Postoperative Osteosarcoma: Tumor Suppression and Bone Regeneration," has been published in Research.

Ocean data assimilation systems combine data assimilation with numerical ocean models to predict ocean conditions. Researchers recently created the Yin-He Global Ocean Data Assimilation and Forecast System (YHGO) to provide more accurate estimations of oceanic conditions than older platforms.

This study introduces a novel nonlinguistic oddball paradigm based on click trains and demonstrates its effectiveness for probing hierarchical temporal processing across species. By bridging macroscopic EEG with mesoscopic ECoG and microscopic single-unit recordings, the work reveals that the auditory system can concurrently track multiple temporal scales and that A1 exhibits superior capacity relative to the MGB for processing complex temporal structures over longer timescales.

This study explores the role of methoxy polyethylene glycol@Elabela-11 (mPEG@ELA-11), a pH-responsive ELA-11 conjugate, in modulating macrophage function and attenuating atherosclerosis, focusing on the protein kinase B (AKT)-mediated endoplasmic reticulum (ER) stress pathway as a molecular target.