Dual-function biomaterials for postoperative osteosarcoma: Tumor suppression and bone regeneration
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Dec-2025 09:11 ET (16-Dec-2025 14:11 GMT/UTC)
Recently, a research team led by Professor Xie Huiqi at Sichuan University conducted a systematic review of dual-function biomaterials that combine anti-tumor and bone regeneration capabilities for postoperative osteosarcoma treatment. The article categorizes existing research findings into three design strategies: conventional dual-function strategies, enhanced anti-tumor strategies, and temporally regulated strategies. It further explores their design principles, therapeutic efficacy, and potential for clinical translation. This review aims to provide insights for establishing an integrated "anti-tumor and bone regeneration" treatment model and offers perspectives on future research directions in the field. The related work, entitled "Dual-Function Biomaterials for Postoperative Osteosarcoma: Tumor Suppression and Bone Regeneration," has been published in Research.
Ocean data assimilation systems combine data assimilation with numerical ocean models to predict ocean conditions. Researchers recently created the Yin-He Global Ocean Data Assimilation and Forecast System (YHGO) to provide more accurate estimations of oceanic conditions than older platforms.
This study explores the role of methoxy polyethylene glycol@Elabela-11 (mPEG@ELA-11), a pH-responsive ELA-11 conjugate, in modulating macrophage function and attenuating atherosclerosis, focusing on the protein kinase B (AKT)-mediated endoplasmic reticulum (ER) stress pathway as a molecular target.