Endogenous AICAR (Acadesine) demonstrates significant therapeutic potential as a phase III clinical agent for the treatment of adverse cardiovascular reactions to coronary artery bypass grafting and as a phase I/II clinical agent for chronic lymphocytic leukemia. However, its biosynthetic mechanism remains poorly defined. Previous study demonstrated that AICAR was significantly enriched in the Fusarium solani mutant veA^OE14, which overexpressed the global regulator VeA. In May 2025, the research team led by Professor Jichuan Kang from the Engineering and Research Center for Southwest Biopharmaceutical Resource of National Education Ministry of China, Guizhou University, published a research paper titled “MtfA, a C2H2 transcriptional regulator, negatively regulates PRPS2-mediated biosynthesis of the adenosine analogue Acadesine in Fusarium solani” in the journal Mycology.

This study elucidated, at the molecular level, the regulatory mechanism by which VeA overexpression enhances AICAR production in Fusarium solani. The team established a three-tier regulatory network model (VeA-MtfA-PRPS2) (Figure 1), laying an important foundation for the engineering of filamentous fungal strains for AICAR biosynthesis.

Perovskite-structured BaFe_0.4Co_0.4Zr_0.1Y_0.1O_3-δ (BFCZY) exhibits proton-electron-oxygen ion triple conductions and high catalytic activity of oxygen reduction (ORR) and oxygen evolution reaction (OER) at low temperatures. Although it has stability problems in a humid air environment, the degradation mechanism of BFCZY and the influences of temperature, steam content and polarization on its stability have been rarely studied. The activity and stability of the BFCZY oxygen electrode are significantly improved through heterointerface engineering by infiltrating the BaCoO₃ (BCO) catalyst. It is imperative to fill this research gap, as it is crucial for promoting the commercial development of reversible protonic ceramic electrochemical cells (R-PCECs).

Highly efficient chemiresistive gas sensors are crucial for numerous applications. Notably, though the generally high working temperature brings fine sensing performance, as well as causing high power consumption, poor safety, and disabled operational stability. Thanks to the cost-effective, simplified structure and integrated diversity, room temperature (RT) operational mode has been put forward and applied in gas sensor devices. However, insufficient limits of detection limit (LOD) and disappointingly long detection time limit their broad applications, meanwhile, the existing sensing mechanism based on the charge transfer between the analyte gas and the oxide surface hampers room temperature gas sensing with low LOD and rapid speed.

A research team at Beihang University, led by Professor Jianghao Wu, has achieved a significant breakthrough in the design of propulsion systems for future low-altitude transport, particularly electric Vertical Take-Off and Landing (eVTOL) aircraft. Their pioneering work, recently published in the Chinese Journal of Aeronautics, introduces a novel analytical framework for ducted propellers, promising to make these advanced flying vehicles smaller, lighter, and more powerful. This research offers vital support for the burgeoning field of advanced air mobility, aiming to alleviate urban traffic congestion and utilize low-altitude airspace.

In the history of aircraft development, maneuverability has always been an important consideration in the design concept of aircraft. The requirements for aerodynamic characteristics are reflected in high lift-to-drag ratio, high lift coefficient, torque stability and so on. The occurrence of dynamic stall will lead to a sharp drop in lift and a rapid rise in drag, resulting in torque oscillation, which seriously restricts the improvement of aircraft performance, and even leads to aircraft crash in severe cases. The traditional passive flow control cannot cope with the real-time and changeable flow field environment, and the emergence of jet control provides a new way to solve the problem of dynamic stall. Although the research of single jet technology has been relatively sufficient, there are few comparative studies on steady jet and synthetic jet, and there is also a lack of related research on dual synthetic jets. Therefore, it is imperative to fill this research gap.